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Pragmatic Play Free Trial

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Pragmatic trials are trials designed to provide information for the real-world practice of clinical. They are typically described as a focus on the practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of standard equipment.

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A pragmatic study that involves a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for pragmatic trials to be able to prove their validity and helps to reduce the chance of bias in the results. However, too much heterogeneity can cause issues with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and to achieve maximum credibility externally. They are usually requested by practitioners and policy makers to inform their decision making. They can also be used to determine the causality of an intervention and its effects. However, they should not be used to replace explanation studies.

The pragmatism idea is controversial and there are doubts regarding whether pragmatic trials could replace explanatory tests or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials, which inform the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study which includes recruitment, design, delivery of the intervention and its follow-up.

There is a positive increase in the number pragmatic trials that have been published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to remember that the majority of these trials were conducted in primary care settings.

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